Food: An Unrecognized Source of Loop Diuretic Resistance
نویسندگان
چکیده
منابع مشابه
Food: an unrecognized source of loop diuretic resistance.
Food significantly affects the pharmacokinetics of oral loop diuretics in healthy individuals, but studies have not been performed in patients with edema. Because of this omission, food's effect on pharmacokinetics has been overlooked and may decrease the pharmacodynamic response in patients who rely on diuretics. Despite this potential interaction, reference manuals do not provide warnings abo...
متن کاملSystems biology of diuretic resistance.
Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that explains thiazide diuretic resistance. The overall...
متن کاملTwice daily loop diuretic dosing time
Torsemide is the first loop diuretic in the pyridine sulfonylurea class. of prescribing furosemide b.i.d., a more appropriate dosing seems to be fourtimes a day.. Moreover, the once daily (q.d.) dosing of torsemide offers improved patient . (furosemide) is a potent diuretic which, if given in excessive amounts, can lead to a chloride not only in the proximal and distal tubules but also in the l...
متن کاملDiuretic therapy and diuretic resistance in cardiac failure.
s 40 venous capacitance within a few minutes before any with oedema is defined as a clinical state where the braking phenomenon occurs before the therapeutic measurable increase in urinary output can be seen [1,2]. This rapid haemodynamic improvement is goal is reached. thought to be due to the release of vasodilatory prostaglandins [3]. However, in a study in patients with severe oedema, i.v. ...
متن کاملLoop diuretic efficiency: a metric of diuretic responsiveness with prognostic importance in acute decompensated heart failure.
BACKGROUND Rather than the absolute dose of diuretic or urine output, the primary signal of interest when evaluating diuretic responsiveness is the efficiency with which the kidneys can produce urine after a given dose of diuretic. As a result, we hypothesized that a metric of diuretic efficiency (DE) would capture distinct prognostic information beyond that of raw fluid output or diuretic dose...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacotherapy
سال: 2004
ISSN: 0277-0008
DOI: 10.1592/phco.24.6.630.34736